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Placental cells have evolved over millions of years to protect and sustain the developing fetus. The placenta is responsible for the exchange of oxygen, carbon dioxide, nutrients and waste between the mother and her fetus; serves as the primary site for formation of fetal blood cells; and helps protect the fetus from attack by the mother’s immune system and from infection. The U.S. National Institutes of Health describes the placenta as “the least understood human organ but arguably one of the most important.” At Pluristem, we have long appreciated the enormous therapeutic potential of the placenta. We collect donated placentas at the time of delivery of healthy, full-term babies, and harness the remarkable capabilities of placental cells to make our cell products. Derived from the placenta, our PLX cells have low immunogenicity and immune-modulatory properties, so they can be administered to patients without the need for HLA-matching.